Isaac's Soul

Isaac's Soul is a passive item added in Pack 1

Effects

 * +50% Tears Multiplier
 * +25% Damage Multiplier
 * +20% Speed Multiplier
 * +15% Range Multiplier
 * +10% Shot Speed Multiplier
 * All damage taken is doubled.

Synergies

 * The Wafer: Negates double damage taken.
 * Cancer: Negates double damage taken after taking damage in room.

Trivia

 * Isaac's Soul sprite is a reference to soul icon from the Four Souls card game.